Graduate student Dimpi Mukhopadhyay was selected to give a short talk on her current work at The Cell Signaling in Cancer Conference: From Mechanisms to Therapy, hosted by the Federation of American Societies for Experimental Biology.
Ayush Passes his QE!
Third-year M.D./Ph.D. student Ayush Kumar is officially a Ph.D candidate at UMass Chan Medical School. His current research interests are focused on mechanisms that contribute to radio-resistance in triple-negative breast cancer. Congrats Ayush!
Spotlight on an unexpected role for PD-L1 in front–rear polarization and directional migration
Our recent publication, PD-LI promotes rear retraction during persistent cell migration by altering integrin β4 dynamics, was highlighted by Sánchez-Álvarez and del Pozo in a JCB this week! You can find their spotlight here.
Dr. Walker presents at the MIT Gylcobio Club
Recent graduate, Dr. Melanie Walker, met with the MIT Glycobio Club on April 6th to discuss her recent publication O-linked α2,3 sialylation defines stem cell populations in breast cancer. Dr. Walker and the MIT trainees had a wonderful exchange on the implications of her work and future projects. These students were able to provide current lab members with a deeper insight into the glycobio field. We appreciate Dr. Walker taking the time to share her work with others and continuing to leave an impact on the field. We would also like to thank the MIT Glycobio Club for organizing this meeting and inviting Dr. Walker and current lab members for open discussion.
AACR Presentations
Recent Mercurio Lab work was a part of two presentations at the annual American Association for Cancer Research meeting.
Graduate student Emmet Karner presented on ferroptosis resistance in epithelial populations of TNBCs mediated by laminin 332 and integrin beta4. His abstract can be found here.
aTyr Pharma presented on our collaborative work highlighting a fully humanized monoclonal antibody targeting the VEGF-NRP2 pathway sensitizing highly aggressive and chemoresistant TNBC subtypes to chemotherapy. Their abstract can be found here.